Rapid Mixer Granulator (RMG) / High shear Mixer: A Review

Rapid mixer granulator is also known as high shear mixer are especially designed to achieve quality mixing and excellent granules at low costs and higher productive too. In pharmaceutical industry rapid mixer granulator plays vital role to mix the ingredients and make granules before compression. Rapid mixer granulators (RMG) are primarily used for tablet manufacturing process which requires homogenous mixing, controlled granule size and at the same time assuring great reduction in processing time.

Parts of RMG:

RMG having different parts like Impeller, Chopper, Discharge port, Pneumatic system, and control panel etc…. Impeller, Chopper are mainly responsible for wet granulation.

Impeller:

At the bottom of the dome shaped stainless steel bowl Impellers are fixed with two half-length blades and two full length blades. Impeller is designed in such a way that full length blades push the material and half-length blade lift the material. Impeller helps to break the wet mass into small pieces and granules.

Chopper:

Chopper has very sharp small blades which are specially designed to cut the wet lumps of material into very small parts which are then mixed by impellers. It is located at bottom of the dome and the size of the granules is totally depends on the speed of the chopper.

Calculation of working capacity of RMG:

First calculate the bulk density of the powder to be mixed, then multiply it with the working capacity in litres and will get the result in kgs.

Principle of working:

In RMG, the formation of granules occurs by rising, whirling, and tumbling motion of the material. Dry mixing is done by adding all ingredients into the RMG by rotation of impeller and chopper at high speed.

During the addition of binder solutions to the powder impeller and chopper are operated at low speed. After the formation of wet mass impeller and chopper are operated at high speed to form the granules of the required size.

Dry mixing is typically 3-5 minutes and wet mixing 5-10 minutes to make the wet mass of material. However, it is not the thumb rule mixing time consumed in processing depends upon the ingredients quantity and particle size. It is validated considering the finished product performance.

After completion of wet mixing process, the powder mixtures are passed through multimill /screening or extrusion/spheronization and finally drying the finished product. After drying granules are ready for compression.

Query:

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About the Author:

Dr. Ajay Kumar Singh, M.Sc. (Gold Medalist), Ph.D. is the author and founder of “Pharma Solutions by Dr. Ajay”.

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