Pharma Solutions by Dr. Ajay

ABSTRACT  Parenteral dosage forms differ from all other pharmaceutical dosage forms because they are injected directly into body tissue through the primary protective systems of the human body, the skin and mucous membranes. They have many advantages like routes of administration, elimination of first pass effect, better absorption. They can be in a solution, suspension, emulsions for injection or infusion, powders for injection or infusion, gels for injection and implants. They are sterile preparations that are administrated directly into the systemic circulation of humans or animals. Its unsafe use can transmit various blood borne pathogens. This article aims to discuss the challenges and its importance for safe injection practice.  I NTRODUCTION  Certain pharmaceutical agents, particularly peptides, proteins, and many chemotherapeutic agents, can only be given parenterally, because they are inactivated in the gastrointestinal tract when given by mouth. Parenterally ad...

ABSTRACT    Excipients, which are an integral part of any formulation, can significantly impact stability, processability, and performance of a dosage form. Some examples are binders, fillers (or diluents), disintegrants, colorants, buffering agents and coatings. One class of functional excipients that are essential in most solid oral dosage forms is “lubricants”. Lubrication plays a key role in successful manufacturing of pharmaceutical solid dosage forms. Although many failures in pharmaceutical manufacturing operations are caused by issues related to selection of lubrication. Selecting a “lubricant” for a formulation requires a systematic approach with careful consideration of the performance of both product and process. Keywords: excipients, functional excipients performance, hydrophobic, lubricants, selection, hydration state, surface area, particle size  INTRODUCTION  Lubricants are commonly added to help in the tabletting of many formulations. Following...

ABSTRACT: Oral drug delivery is most commonly route of administration, when compared to all other route of administration. Oral route is most convenient, safe route of administration. Solid medicaments may be administered orally like tablets, capsules, pills, powders etc. One of the solid dosage form  administered orally is tablet. One of the most critical steps in tablet is produce the tablets without any physical defect. This review provides a comprehensive report of problems. It is based on my personal experience and detailed study of several pharmaceuticals paper. Keywords: Oral drug, Oral route, Direct Compression (DC), tablets, Processing Problems.   INTRODUCTION: Tablets are solid dosage form manufactured either by dry granulation, wet granulation or direct compression containing medicaments with or without excipients, intended to produce desired pharmacological response. Various types of tablets are being manufactured according the route of administration an...