Pharma Solutions by Dr. Ajay

Introduction: Presently pharmaceutical industries are focusing on development of sustained release formulations due to its inherent boons. Sustained release dosage forms are designed to release a drug at a predetermined rate by maintaining a constant drug level for a specific period of time. The basic rationale of sustained release drug delivery system optimizes the biopharmaceutical, pharmacokinetic and pharmacodynamics properties of a drug in such a way that its utility is maximized, side-effects are reduced and cure of the disease is achieved. Sustained release (SR) preparations are not new but several new modifications are being introduced. Rising number of patent expirations and soaring need for pediatric and geriatric dosage forms are providing a boost to the growth of the market. Growing awareness regarding added benefits provided by sustained release formulations is also stimulating the growth of the market.   SR has received most of the attention because of the fact that...

  Solid oral dosage forms are most acceptable dosage forms especially tablets are most widely accepted by people of different age groups. A multifunctional and multiple unit system for oral use are developed by filling versatile mini tablets in a capsule. It is a multifunctional and multiple unit system for oral use and can be developed by filling versatile tablets in a capsule, for example: Immediate release mini tablets, Rapid-release Mini-Tablets (RMTs), Sustained release Mini-Tablets (SMTs), Pulsatile Mini-Tablets (PMTs), and Delayed-onset Sustained release Mini-Tablets (DSMTs). In this technology we can reduce the size of the tablet such that it could be enclosed in a capsule, and then deployed within one single dosage form. Mini tablets are multiple unit dosage forms and are advantageous than pellets or any other oral dosage forms as they are easy to manufacture, and stability problems are less. The oral controlled release drug delivery system included two types of dosage for...

  Medicated chewing gums (MCG) have a wide range of applications in health care, including drug delivery and neutraceuticals. These gums are used for the prevention and treatment of motion sickness and dental caries and smoking for cessation. The popularity of medicated chewing gums as drug delivery systems is increasing due to their advantages such as non-invasiveness, easy administration, and faster metabolism through the liver or gut wall. Moreover, the trend of using biodegradable chewing gums is increasing due to a ban on synthetic polymer-based chewing gums in Singapore and other parts of the world.    Drugs released while chewing can either be absorbed directly into the bloodstream via the buccal membrane or it could be swallowed with saliva and absorbed in the gastrointestinal (GI) tract. As most of the given drug in MCGs gets absorbed, a reduced dose may be required, lowering the chances of side effects. The drug concentration that is absorbed via the GI tract is...

Brand is very important for marketing. Customer knows the product by its brand. Consistency in quality plays a vital role in branding of a product. I am discussing six ways to develop quality consistency which will automatically get transformed into a brand, especially in pharmaceuticals. The given example will make you understand the actual meaning of brand. E.g., Crocin is India’s leading analgesic brand in the non – prescription(over-the-counter) analgesics category with a wide range of variants in both solid and liquid formats. Internationally, Crocin is marketed as Panadol and sells in more than 80 countries. More than 2 million tablets of Crocin are sold every day in India but majority population doesn’t know its manufacturer as brand matters more than the company’s name. Brand identity is a collection of visual elements that makes your business unique and different from other businesses. Brand identity is what you, customers, and prospective customers can see and is d...

pH modifier excipients are used in the pharmaceutical industry due to their antioxidant properties. pH modifiers can help maintain the stability of pharmaceutical and can also be used as preservatives. For pH-modification, the addition of a base or an acid is often preferred over the use of buffers. Acidic or basic ingredients (pH modifiers) can be intentionally added to a formulation for the sole purpose of modifying the ‘pH.’ but parameters like salt selection and pH value are critical in the pre-formulation stages, the use of excipients to make pH adjustments is also a significant factor in designing the drug’s formulation and delivery and should not be overlooked. Adjustment of the pH value is the simplest and most commonly used method of increasing the water solubility of ionisable compounds. The solubility of therapeutic agents is pH dependent. The solubility of acids and bases increases as the degree of ionization increases. The solubility of acidic compounds increases as th...