Pharma Solutions by Dr. Ajay

  Solid oral dosage forms are most acceptable dosage forms especially tablets are most widely accepted by people of different age groups. A multifunctional and multiple unit system for oral use are developed by filling versatile mini tablets in a capsule. It is a multifunctional and multiple unit system for oral use and can be developed by filling versatile tablets in a capsule, for example: Immediate release mini tablets, Rapid-release Mini-Tablets (RMTs), Sustained release Mini-Tablets (SMTs), Pulsatile Mini-Tablets (PMTs), and Delayed-onset Sustained release Mini-Tablets (DSMTs). In this technology we can reduce the size of the tablet such that it could be enclosed in a capsule, and then deployed within one single dosage form. Mini tablets are multiple unit dosage forms and are advantageous than pellets or any other oral dosage forms as they are easy to manufacture, and stability problems are less. The oral controlled release drug delivery system included two types of dosage forms:

  Medicated chewing gums (MCG) have a wide range of applications in health care, including drug delivery and neutraceuticals. These gums are used for the prevention and treatment of motion sickness and dental caries and smoking for cessation. The popularity of medicated chewing gums as drug delivery systems is increasing due to their advantages such as non-invasiveness, easy administration, and faster metabolism through the liver or gut wall. Moreover, the trend of using biodegradable chewing gums is increasing due to a ban on synthetic polymer-based chewing gums in Singapore and other parts of the world.    Drugs released while chewing can either be absorbed directly into the bloodstream via the buccal membrane or it could be swallowed with saliva and absorbed in the gastrointestinal (GI) tract. As most of the given drug in MCGs gets absorbed, a reduced dose may be required, lowering the chances of side effects. The drug concentration that is absorbed via the GI tract is subjected to

Brand is very important for marketing. Customer knows the product by its brand. Consistency in quality plays a vital role in branding of a product. I am discussing six ways to develop quality consistency which will automatically get transformed into a brand, especially in pharmaceuticals. The given example will make you understand the actual meaning of brand. E.g., Crocin is India’s leading analgesic brand in the non – prescription(over-the-counter) analgesics category with a wide range of variants in both solid and liquid formats. Internationally, Crocin is marketed as Panadol and sells in more than 80 countries. More than 2 million tablets of Crocin are sold every day in India but majority population doesn’t know its manufacturer as brand matters more than the company’s name. Brand identity is a collection of visual elements that makes your business unique and different from other businesses. Brand identity is what you, customers, and prospective customers can see and is diffe

pH modifier excipients are used in the pharmaceutical industry due to their antioxidant properties. pH modifiers can help maintain the stability of pharmaceutical and can also be used as preservatives. For pH-modification, the addition of a base or an acid is often preferred over the use of buffers. Acidic or basic ingredients (pH modifiers) can be intentionally added to a formulation for the sole purpose of modifying the ‘pH.’ but parameters like salt selection and pH value are critical in the pre-formulation stages, the use of excipients to make pH adjustments is also a significant factor in designing the drug’s formulation and delivery and should not be overlooked. Adjustment of the pH value is the simplest and most commonly used method of increasing the water solubility of ionisable compounds. The solubility of therapeutic agents is pH dependent. The solubility of acids and bases increases as the degree of ionization increases. The solubility of acidic compounds increases as the pH

MUPS technology has been adopted by the pharmaceutical industry as an alternative to conventional technology. MUPS can be formulated into commonly used dosage forms like tablets and capsules, which makes them more economical and stable in terms of shelf life of the final dosage form. Generally, MUPS are divided into two types of systems one is comprised of coated pellets and the other one is with uncoated pellets. The coated pellets will be acting as a reservoir system and uncoated pellets follow a general matrix pattern. In both cases, excipients should be separated from systems and should not interfere with the functionality of particles.  Types of MUPS Formulation: A. MUPS with matrix pellets B. MUPS with pellet coated. The pellets have a spherical core that contains or is coated with the active ingredient and have one or more protective layers (cellulosic and acrylic polymers) to control drug release. Offering increased bioavailability and improved pharmacological properties, inc

  ABSTRACT The objective of this article is to study how technology is transferred in pharmaceutical industry. The article attempts to discuss about the technology transfer process, importance of technology transfer, goals of technology transfer, robust technology transfer by QBD approach, steps involved in technology transfer in the pharmaceutical industry and understand the aspects related with technology transfer. Keywords: technology transfer, pharmaceutical industry, goals, robust transfer by QBD, steps involved. INTRODUCTION [1] A proper technology transfer (TT) is both essential and important to drug discovery and development for new medicinal products. It is also required to upgrade drug quality planned during research development and to final product during manufacturing as well as to guarantee that stable quality is transferred. Technology transfer (TT) is defined as “the transfer of the manufacturing process for a new pharmaceutical Drug Substance (DS) and Drug Product (DP)