Pharma Solutions by Dr. Ajay

ABSTRACT Super disintegrants (SDTs) are the class of compounds which primarily aid in the solid dosage forms for the rapid disintegration. This class of disintegrants have been shown to be effective at excipient concentrations as low as 1 to 10% when compared to traditional disintegrant starches, which may need concentrations as high as 20%. To date there have been three primary classes of modified starch used as SDTs in the formulation of solid dosage forms: sodium starch glycolate (SSG), croscarmellose sodium (CCS), and synthesized polymer crospovidone (XP). The inclusion of the right super disintegrant is a prerequisite to get optimal bioavailability in tablets and capsules which need rapid disintegration. Super disintegrants are used to improve the efficacy of solid dosage forms. This is achieved by decreasing the disintegration time which in turn enhances the drug dissolution rate. Keywords: super disintegrants, croscarmellose sodium, sodium starch glycolate, crospovidone, swellin

ABSTRACT  Now-a-days, lyophilized injection dosage form is extensively used to improve the bioavailability, stability, solubility and patient compliance. The lyophilized injection is used for better patient compliance especially in bed ridden patients and for attaining maximum bioavailability, improved stability. The lyophilized injection reconstitutes before injection to produce liquid injection. This review includes a detailed updated concept on lyophilized injection. Keywords: Lyophilized injection, parenteral, freezing, sublimation, desorption freeze drying INTRODUCTION Lyophilization, or freeze-drying, is a crucial process technology for many parenteral drugs, and an essential part of extending product shelf life.  Lyophilization is a water removal process through which perishable items are preserved. This process boosts the shelf life of the material and also makes them easier to transport. Lyophilized injections are also prescribed to attain maximum bioavailability and stabili