Pharma Solutions by Dr. Ajay

pH modifier excipients are used in the pharmaceutical industry due to their antioxidant properties. pH modifiers can help maintain the stability of pharmaceutical and can also be used as preservatives. For pH-modification, the addition of a base or an acid is often preferred over the use of buffers. Acidic or basic ingredients (pH modifiers) can be intentionally added to a formulation for the sole purpose of modifying the ‘pH.’ but parameters like salt selection and pH value are critical in the pre-formulation stages, the use of excipients to make pH adjustments is also a significant factor in designing the drug’s formulation and delivery and should not be overlooked. Adjustment of the pH value is the simplest and most commonly used method of increasing the water solubility of ionisable compounds. The solubility of therapeutic agents is pH dependent. The solubility of acids and bases increases as the degree of ionization increases. The solubility of acidic compounds increases as the pH

MUPS technology has been adopted by the pharmaceutical industry as an alternative to conventional technology. MUPS can be formulated into commonly used dosage forms like tablets and capsules, which makes them more economical and stable in terms of shelf life of the final dosage form. Generally, MUPS are divided into two types of systems one is comprised of coated pellets and the other one is with uncoated pellets. The coated pellets will be acting as a reservoir system and uncoated pellets follow a general matrix pattern. In both cases, excipients should be separated from systems and should not interfere with the functionality of particles.  Types of MUPS Formulation: A. MUPS with matrix pellets B. MUPS with pellet coated. The pellets have a spherical core that contains or is coated with the active ingredient and have one or more protective layers (cellulosic and acrylic polymers) to control drug release. Offering increased bioavailability and improved pharmacological properties, inc