Pharma Solutions by Dr. Ajay

  ABSTRACT The most common and preferred route of drug administration is through the oral route. ODTs are gaining importance among novel oral drug-delivery system as they have improved patient compliance and have some additional advantages compared to other oral formulation. They are also solid unit dosage forms, which disintegrate in the mouth within a minute in the presence of saliva due to super disintegrants in the formulation. Thus, this type of drug delivery helps a proper peroral administration in pediatric and geriatric population where swallowing is a matter of trouble. Various scientists have prepared ODTs by following various methods. However, the most common method of preparation is the compression method. Other special methods are molding, melt granulation, phase-transition process, sublimation, freeze-drying, effervescent method, cotton candy process, mass-extrusion etc. Since these tablets dissolve directly in the mouth, so, their taste is also an important factor. Vario