Fundamental aspect of super disintegrants: A concise review
ABSTRACT Super disintegrants (SDTs) are the class of compounds which primarily aid in the solid dosage forms for the rapid disintegration. This class of disintegrants have been shown to be effective at excipient concentrations as low as 1 to 10% when compared to traditional disintegrant starches, which may need concentrations as high as 20%. To date there have been three primary classes of modified starch used as SDTs in the formulation of solid dosage forms: sodium starch glycolate (SSG), croscarmellose sodium (CCS), and synthesized polymer crospovidone (XP). The inclusion of the right super disintegrant is a prerequisite to get optimal bioavailability in tablets and capsules which need rapid disintegration. Super disintegrants are used to improve the efficacy of solid dosage forms. This is achieved by decreasing the disintegration time which in turn enhances the drug dissolution rate. Keywords: super disintegrants, croscarmellose sodium, sodium starch glycolate, crospovidone, swellin